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COSMOSDB

COSMOSDB uses data from several sources. Please read carefully the following paragraphs about fair usage:

Cosmetics Europe: The data used in this database is prepared by and for the scientific community. Correct interpretation of the data depends upon multiple factors, and should be used in the light of expert scientific interpretation.
US FDA: U.S. Food and Drug Administration data included in COSMOS are not safety determinations with respect to specific food additives or GRAS ingredients. This database does not necessarily represent the views of the U.S. government and should not be construed as FDA guidance or policy.
Chemical structures and compound information, including registry numbers and names were kindly provided by CERES, P&G and DSSTox.

QA statistics

Based on the results of a QA on chemical structures, the approximate percentage of inaccurate structures in production v1.0 of the database is 4.3% if stereo chemistry is ignored and 9.7% when stereo chemistry is considered. Approximately 2.2% of the names may contain errors and 0.5% of the records may have incorrect Registry Numbers. The results of a QA on oRepeatTox DB indicates that xx% of studies may have inaccurate records.

COSMOS Project

COSMOS is one of seven projects forming the SEURAT-1 cluster. SEURAT is a European research initiative with the long-term goal of achieving "Safety Evaluation Ultimately Replacing Animal Testing".
COSMOS is a unique collaboration addressing the safety assessment needs of the cosmetics industry, without the use of animals. The main aim of COSMOS is to develop freely available tools and workflows to predict the safety to humans following the use of cosmetic ingredients. This will be achieved using computational tools such as applying thresholds of toxicological concern (TTC), in silico toxicology, in vitro data and physiologically-based pharmacokinetic (PBPK) modelling.
COSMOS Official Web Page